The effect of digoxin on mortality
WebMar 6, 2024 · Patients with a serum digoxin concentration ≥1.2 ng/ml had a 56% increased hazard of mortality (adjusted HR, 1.56; 95% confidence interval [CI], 1.20–2.04). When analyzed as a continuous variable, serum digoxin concentration was associated with a 19% higher adjusted hazard of death for each 0.5 ng/ml increase (p = 0.0010); these results ... WebApr 12, 2024 · The incidence rate of all-cause mortality in the total sample was 0.18 and 0.22 in patients on beta-blocker plus digoxin and beta-blocker alone, respectively [incidence rate ratio (IRR) = 1.25; 95 ...
The effect of digoxin on mortality
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WebJan 19, 2024 · Adverse Effects. Digoxin toxicity is clinically relevant as it can lead to fatal cardiac arrhythmias. The estimated frequency is at about 0.8 to 4% of patients on steady digoxin therapy. ... The association between digoxin use and mortality has raised many concerns among researchers, as there is some evidence that it seems to increase … WebAug 6, 2024 · Background: The deleterious effects of discontinuation of digoxin on outcomes in ambulatory patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) receiving angiotensin-converting enzyme inhibitors are well-documented. Objectives: The authors sought to determine the relationship between digoxin …
WebWe included systematic reviews and meta-analyses of observational studies investigating digoxin effects on mortality of adult patients with AF and/or HF. The primary outcome was all-cause mortality; secondary outcome was cardiovascular mortality. Certainty of evidence was evaluated by the Grading of Recommendations Assessment, Development and ... WebMar 1, 2009 · The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997; 336: 525–533. Crossref Medline Google Scholar; 6 Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J, for The Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and ...
WebNational Center for Biotechnology Information WebJan 16, 2013 · In a stepwise examination of the multivariate Cox regression model for all-cause mortality, the HR for the association between digoxin and all-cause mortality ranged between 1.36 and 1.66, and the greatest effect was seen after adding NYHA functional class. 12 In their Discussion, the authors also mention that high serum levels were …
WebEffect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. ... Ahmed A, Rich MW, Fleg JL, et …
WebMar 8, 2024 · The clinical effects of digoxin on all-cause mortality, serious adverse events, quality of life, heart failure, and stroke are unclear based on current evidence. Digoxin seems to be superior compared with placebo in reducing the heart rate, but inferior compared with beta blockers. The long-term effect of digoxin is unclear, as no trials ... serie cornebidouilleWebWe included systematic reviews and meta-analyses of observational studies investigating digoxin effects on mortality of adult patients with AF and/or HF. The primary outcome … serie con maite perroniWebDigoxin had no effect on all-cause or cause-specific mortality or on all-cause or cardiovascular hospitalization. Use of digoxin was associated with a trend toward a … série corleone en français épisodesThe role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains controversial. We studied the effect of digoxin on mortality and hospitalization in a randomized, double-blind clinical trial. See more In the main trial, patients with left ventricular ejection fractions of 0.45 or less were randomly assigned to digoxin (3397 patients) or placebo (3403 patients) in addition to diuretics and angiotensin-converting–enzyme … See more In the main trial, mortality was unaffected. There were 1181 deaths (34.8 percent) with digoxin and 1194 deaths (35.1 percent) with placebo (risk ratio when digoxin was … See more Digoxin did not reduce overall mortality, but it reduced the rate of hospitalization both overall and for worsening heart failure. These findings define more precisely the role of … See more serie con demet ozdemirWebOct 31, 2002 · There was an absolute difference of 5.8 percent (95 percent confidence interval, 0.5 to 11.1) between men and women in the effect of digoxin on the rate of death … série coréenne netflix horreurWebOct 31, 2024 · Poor understanding of digoxin’s limitations can lead to inappropriate use of this agent in patients with atrial fibrillation and may explain, in part, recent reports of associations between digoxin use and increased mortality. 5, 6 In the acute care setting, the peak effect of digoxin is delayed by several hours (about 3–6 h) because of the ... palmares village prefere des francaisWebJan 20, 2024 · “The effects of digoxin on mortality and morbidity in patients with heart failure”. N Engl J Med. vol. 336. 1997. pp. 525-33. (Classic, large scale, multicenter randomized clinical trial demonstrating the important contribution digoxin makes to heart failure patients in normal sinus rhythm. The database has been plumbed repeatedly over … série continental