S trac trial
Web25 Feb 2024 · The Tranexamic Acid (TrAc) trial (ClinicalTrials.gov: NCT02966236) was a prospective, randomised, double-blind, placebo-controlled trial conducted to investigate … WebThe primary outcome is investigator-reported disease-free survival (DFS). Given the results of the ASSURE and S-TRAC trials, and blinded to SORCE outcomes, we revised the primary analysis to compare three years of sorafenib (arm C) vs placebo (arm A) to focus on the question of longer exposure to sorafenib. Results
S trac trial
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Web10 Sep 2024 · Sunitinib (anti-VEGF) was approved in the US as adjuvant treatment for patients with high risk of recurrence based on a DFS benefit observed in the S-TRAC trial. 1 Other trials of anti-VEGF agents have not met their primary efficacy endpoints, and none, including sunitinib, have demonstrated an overall survival benefit. WebTRAK-ER is a randomised trial of early detection of molecular relapse with circulating tumour DNA tracking and treatment with palbociclib plus fulvestrant, versus standard endocrine therapy in patients with ER positive HER2 negative breast cancer.
WebThe S-TRAC (sunitinib, positive), PROTECT (pazopanib), ARISER (girentuximab), and ATLAS (axitinib) trials showed contradicting results regarding the efficacy of adjuvant targeted …
Web31 Aug 2024 · This changes the first-line therapy for the patients entered into CARMENA and SURTIME. In the pivotal CheckMate 214 trial, 187 mRCC patients were included with their primary tumour in place demonstrating a survival benefit with immune checkpoint inhibition. Web13 Sep 2006 · A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer (S-TRAC) The …
Web14 Sep 2024 · Abstract. Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in patients with locoregional high-risk renal cell carcinoma (RCC) in the S-TRAC trial (ClinicalTrials.gov NCT00375674). The 16-gene Recurrence Score (RS) assay was previously developed and validated to estimate risk for disease recurrence in patients with …
WebTRAK-ER is a randomised trial of early detection of molecular relapse with circulating tumour DNA tracking and treatment with palbociclib plus fulvestrant, versus standard … prodigal son actorsWebHe then presented a comparison between the S-TRAC study and KEYNOTE-564. Notably, among patients on the placebo control arm, 2-year DFS rates were similar between the two trials (68% in S-TRAC and 68.1% in KEYNOTE-564). Toxicity higher in S-TRAC with use of sunitinib compared to KEYNOTE-564 with the use of pembrolizumab. reinforcing lap splice chartsWeb10 Oct 2024 · The S-TRAC trial was conducted in accordance with the ethics principles of the Declaration of Helsinki and Good Clinical Practice guidelines, defined by the … prodigal son assemblyWebNational Center for Biotechnology Information reinforcing ligamentsWeb17 May 2024 · The strong prognostic performance of the 16-gene RS assay was confirmed in S-TRAC, and the RS assay is now supported by level IB evidence, which may help identify patients at high risk for recurrence who may derive higher absolute benefit from adjuvant therapy. Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in … prodigal son activity for kidsWebClinical Trial Practitioner Assistant. Accepting applications until: 26-Apr-2024 23:59. View job details. reinforcing loft floor joistsWeb24 Apr 2024 · The ATLAS trial, investigating adjuvant axitinib versus placebo in renal cell carcinoma (RCC), was stopped for futility at a preplanned interim analysis. We report subgroup outcome analyses by ethnicity, time on treatment, dose modification and toxicity. ... (DFS) benefit of sunitinib versus placebo in the S-TRAC trial. 4. Pfizer Inc Sutent ... reinforcing loaded steel compression members